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Year : 2016  |  Volume : 3  |  Issue : 2  |  Page : 74-79

Importance of ferritin in sera and cerebrospinal fluid as both a predictive and an etiodiagnostic biomarker in ischemic stroke: a single-center prospective study

1 Department of Clinical Pathology, Pharos University in Alexandria, Faculty of Medicine, Alexandria University, Alexandria, Egypt
2 Department of Neurology, Faculty of Medicine, Alexandria University, Alexandria, Egypt
3 Critical Care Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt

Correspondence Address:
Hala Demerdash
Clinical Pathology, Clinical Pathology Department Alexandria University Hospitals, Faculty of Pharmacy Pharos University in Alexandria, 75 Ismail Serry street, Smouha 21311 Alexandria
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2356-9115.189790

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Background and aim Trace metals such as iron and its storage protein ferritin are known to play an important role in stroke and other neurologic disorders. This prospective study was designed to determine whether cerebrospinal fluid (CSF) ferritin levels aid in evaluation of stroke severity and its prognosis. Patients and methods Thirty-two patients with a diagnosis of acute stroke due to intrinsic or atherosclerotic vessel pathology were included in the study within 24 h from onset of symptoms. Immediately after admission, the clinical condition of the patient was evaluated using the Canadian Stroke Scale and was determined periodically during follow-up. Serum and CSF ferritin levels were assayed and correlated with the known biomarker amyloid β protein 1-42. Results Serum ferritin level revealed significantly greater values in patients with larger-sized lesions (P<0.01) and deteriorated neurologic condition during clinical follow-up. CSF and serum ferritin levels were correlated with neurologic deficit (r=0.50, P<0.001). There was no significant correlation between amyloid β protein 1-42 and ferritin levels (r=0.07, P=0.7). Serum ferritin level and large-sized lesions were independently associated with stroke due to Intracranial atherosclerotic disease pathology. Increased serum ferritin levels correlated with severity of stroke and the size of the lesion. Conclusion Our results revealed that elevated values of CSF and serum ferritin may indicate a poor prognosis in terms of neurologic deterioration in intracranial atherosclerotic (ICAD)-induced stroke patients.

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