• Users Online: 382
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
Year : 2017  |  Volume : 4  |  Issue : 4  |  Page : 235-238

Sedation with intrathecal clonidine versus fentanyl with bupivacaine in elective cesarean section in a sample of Egyptian parturients

1 Anesthesia Department, Alexandria Faculty of Medicine, Alexandria, Egypt
2 Anesthesia Department, Magrabi Hospital, Jeddah, Saudi Arabia

Correspondence Address:
Mohammad Hazem I Ahmad Sabry
Anesthesia Department, Faculty of Medicine, Khartoum Square, Shlalat, Alexandria, 21111
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/roaic.roaic_116_16

Rights and Permissions

Background and objective Regional analgesia has become the preferred technique in obstetrics. Spinal analgesia has many advantages, including being a single injection, being easier to administer, and being faster to take effect. Patients and methods This study was carried out on 40 parturients scheduled for cesarean sections with spinal analgesia who were categorized as follows: the fentanyl group − 20 parturients received 2 ml of 0.5% hyperbaric bupivacaine and 25 μg fentanyl; and the clonidine group − 20 parturients received 2 ml of 0.5% hyperbaric bupivacaine and 75 μg clonidine. Hemodynamic measurements, sensory blockade, pain intensity using visual analog scale (VAS) and time to first request for analgesia, motor blockade, perioperative side effects or complications, fetal well-being using Apgar score, and both parturient and surgeon satisfaction were recorded and statistically analyzed. Results The parturients who received intrathecal clonidine had a higher level and faster onset of sensory blockade and delayed regression of sensory level compared with those who received intrathecal fentanyl. Regarding the changes in pain intensity measured by VAS, the clonidine group revealed low VAS compared with the fentanyl group immediately after spinal anesthesia and up to 3 h postoperatively with earlier and multiple requests for analgesics in the fentanyl group. On comparing both groups regarding onset of motor block and its regression using the modified Bromage score, we noticed slower onset and regression of motor block in the fentanyl group with longer duration of motor block compared with the clonidine group. Sedation was significantly higher in the clonidine group (25%) than in the fentanyl group. The incidence of nausea and vomiting was significantly higher in parturients who received intrathecal fentanyl (30%) than in those who received intrathecal clonidine (5%) (P<0.05). Conclusion Use of intrathecal clonidine for cesarean section results in better sensory blockade and early recovery of motor blockade as compared with the use of intrathecal fentanyl. Intraoperative sedation is significantly better in the clonidine group.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded65    
    Comments [Add]    

Recommend this journal