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Year : 2017  |  Volume : 4  |  Issue : 3  |  Page : 99-107

Serial heparin-binding protein compared with sequential organ failure assessment, acute physiological and chronic health evaluation ii, multiple organ dysfunction and charlson scores as predictors of mortality in critically ill septic patients

1 Department of Critical Care Medicine, Cairo University, Cairo, Egypt
2 Department of Critical Care Medicine, Shebin Elkom Teaching Hospital, Al Minufiyah, Egypt

Correspondence Address:
Nora Ismail Abbas
Department of Critical Care Medicine, Cairo University, Cairo
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/roaic.roaic_83_16

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Introduction Early detection and management of severe sepsis is crucial for successful outcome. We hypothesized that the progression of sepsis to severe sepsis is preceded by vascular leakage, which is caused by neutrophil-derived mediators, as heparin-binding protein (HBP). Aim The aim of the study was to identify the role of serial HBP measurement as a predictor of morbidity and mortality in critically ill septic patients in comparison with sequential organ failure assessment (SOFA), acute physiological and chronic health evaluation II (APACHE II) score, multiple organ dysfunction (MODS) scores, and Charlson scores. Settings and design This was an observational prospective controlled study. Materials and methods Patients were classified into two groups: group I, which included 40 patients with evident sepsis; and group II (control group), which included 10 critically ill nonseptic patients. Results Statistically significant difference was detected between survivors and nonsurvivors in max SOFA score, APACHE II, MODS, white blood cells, and serial HBP. Receiver-operating characteristic curve using admission HBP for prediction of severe sepsis showed a sensitivity of 94.7% and specificity of 100% at cut-off level more than 1.9 ng/ml, and for prediction of mortality the sensitivity was 91.6% and specificity 100% at cut-off level more than 1.9 ng/ml. Conclusion Serial plasma HBP levels can predict severe sepsis and mortality in ICU septic patients without statistically significant difference compared with SOFA, APACHE, and MODS scores.

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