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ORIGINAL ARTICLE
Year : 2015  |  Volume : 2  |  Issue : 4  |  Page : 126-131

Lung recruitment maneuver with and without nebulized albuterol for acute lung injury: a randomized, controlled study


1 Department of Anesthesia, Qena Faculty of Medicine, South Valley University, Qena, Egypt
2 Department of Chest Diseases, Qena Faculty of Medicine, South Valley University, Qena, Egypt

Correspondence Address:
Salah M Asida
Department of Anesthesia, Qena University Hospital, Qena Faculty of Medicine, South Valley University, Qena 83523
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2356-9115.178908

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Background β2-Adrenoceptor agonists accelerate the resolution of pulmonary edema in experimental and clinical studies. We tested the hypothesis that combining nebulized albuterol with lung recruitment maneuver (RM) during mechanical ventilation would improve oxygenation and accelerate the resolution of pulmonary edema more than would RM alone in patients with acute lung injury (ALI) and/or acute respiratory distress syndrome (ARDS). Materials and methods In this randomized, controlled, single-blinded study, 60 patients admitted to the ICU of Qena University Hospitals and suffering from ALI and/or ARDS were recruited. All patients were subjected to the lung RM. They were assigned to two equal groups: the albuterol group (30 patients), in which patients were medicated with nebulized albuterol 1 mg diluted in 10 ml saline; and the control group (30 patients), in which patients were given 10 ml nebulized saline instead of albuterol. This regimen was repeated every 8 h for 3 days. Alveolar fluid samples were withdrawn before and 1 h after the lung recruitment for protein concentration measurement in the alveolar fluid. Results We found a significant difference between the two groups regarding PaO2 (P = 0.003) and PaO2/FiO2 (P = 0.023) before and after RM ± albuterol. No significant difference between the two groups was found regarding alveolar fluid clearance and alveolar protein concentration. Conclusion RM with nebulized albuterol improved oxygenation but the addition of albuterol was not beneficial regarding alveolar fluid clearance in terms of lowering alveolar protein concentration in ALI/ARDS patients. Trial registration The study was registered in the Australian Newzealand clinical trial registry (ANZCTR), with the number, ACTRN12613000836730, and website, http://www.ANZCTR.org.au/ACTRN12613000836730.aspx.


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